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In solid tumor investigations, AMPK blocked -catenin trans-activation via activation-dependently inhibiting AKT-mediated phosphorylation of the -catenin S552 site, which in turn reduced the transcript levels of CD274 (PD-L1) in cancer cells (70)

Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat

Moreover, fungi stand out among eukaryotes due to their potent impact on the host immune system, exerting diverse immunological effects (32)

As the alcohol concentration increases, it stimulates the growth of acetic acid bacteria, which produces beneficial organic acids such as acetic acid and gluconic acid, both of which have been reported to possess antimicrobial properties 8

36 The incidence of DILI due to ICI was reported to be 0.814.6% for the CTLA-4 inhibitor ipilimumab and 2.716% for PD-1/PD-L1 inhibitors such as nivolumab